NHS have reached out with information and signposting of the substance Nitazenes.  

o   Nitazenes pose a substantial risk of overdose due to their high potency. 
o   Detections in harms and in the wider drugs market are increasing. 
o   Metonitazene, isotonitazene, protonitazene and N-pyrrolidino-etonitazene have been detected in deaths. 
o   Please re-read and share the alert on nitazene-type opioids
o   Data on detections can be found in the RADAR quarterly report

o   Naloxone effectively reverses opioid overdoses. 
o   Multiple doses may be necessary to reverse overdoses from nitazenes. 
o   Doses should be administered one at a time, waiting 2-3 minutes between each dose while watching for a response. 
o   If multiple kits have been administered but they are having no effect, it may be that this is a different type of medical emergency. This is one reason an ambulance is called immediately, so that professional assistance can be offered as soon as possible. 
o   Ensure your setting is prepared and ready to respond to overdose situations. 
o   Increase and optimise the availability of naloxone. 
o   Promote and discuss realistic harm reduction measures that mirror those recommended for opioid and polydrug use – be very cautious, dose low, go slow, avoid mixing, use in company, carry naloxone.  
Opioid overdose signs 
·       unconsciousness (won’t wake with a shout or a shake) 
·       unable to speak or respond 
·       shallow (or slowed) breathing 
·       snoring or rasping breaths 
·       blue lips 
·       pale skin 
·       pin-point pupils 
For resources, visit at STOP THE DEATHS

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